Haemopoietic stem cell transplants (HSCT) are used to treat a range of both haematological and non-haematological malignancies and other serious conditions. These stem cells may come from bone marrow, peripheral blood or cord blood. Transplants can be allogeneic, using stem cells from a donor, or autologous, where the patient’s own stem cells are harvested and then returned, usually after high-dose conditioning chemotherapy (depending on the disease). HSCT are used as treatment for many indications including acute and chronic leukaemias, lymphoma, multiple myeloma, some solid tumours and other haematological conditions such as myelodysplasia, aplastic anaemia, thalassemia and immune disorders.
The Australasian Bone Marrow Transplant Recipient Registry (ABMTRR) was established in 1992 to record details of all HSCT. The ABMTRR operates under the auspices of the Bone Marrow Transplant Society of Australia and New Zealand. Contributing centres provide registrations of new transplants to the ABMTRR and also information on the progress of previous transplant patients. Currently the database holds information on over 34,000 HSCT from 52 centres around Australia and New Zealand. Annual transplant figures have increased each year since 2006, with more than 2,000 transplants performed each year since 2015.
Arrow has supported the registry since it was first established, and has continued its support each year by contributing towards the production and distribution costs of the Annual Data Summary. This document is distributed to more than 500 clinicians and researchers from Australia and New Zealand. Data are provided for research projects and ad hoc requests from clinicians, researchers and government officials. The information may be used for publications in peer reviewed journals, presented at conferences (both local and international) and used by hospital and government departments for administrative, quality and planning purposes.
Since July 2010 the ABMTRR has received some basic operational funding from all Australian Governments, through the Commonwealth Department of Health and Ageing. The ABMTRR is now accommodated in The Kinghorn Cancer Centre in Victoria St, Darlinghurst, sharing a modern open plan office with research and clinical trials staff from St Vincent’s Hospital Haematology and Oncology and the Garvan Institute of Medical Research.
ASTRO (Australasian Stem cell Transplants Online), the ABMTRR online database, has been up and running since 2013. The study management module, developed with support from Arrow, is currently being used for 10 research projects. These diverse projects include two prospective studies investigating aspects of haplo-identical transplants, a long term follow up pilot study in collaboration with BMT Network NSW, and several studies looking at the impact of various genetic mutations on transplant outcomes.